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When copper is in excess, it can cause oxidative stress and damage to cells, which increases the demand for glutathione to neutralize the free radicals produced

Reduced glutathione levels can lead to increased oxidative stress and impaired detoxification, while decreased methylation can lead to a range of health issues, including mood disorders, cognitive dysfunction, and cancer

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In addition, a low level of GPx3 is an independent predictive marker of the local recurrence of early-stage invasive breast cancer in patients undergoing breast-conserving surgery and radiotherapy, regardless of the patients clinicopathological parameters [104]